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KMID : 1130620080040010017
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Journal of Clinical Neurology
2008 Volume.4 No. 1 p.17 ~ p.22
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β-Fibrinogen Gene -455 G/A Polymorphism in Korean Ischemic Stroke Patients
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Lee Seung-Han
Park Man-Seok
Cho Ki-Hyun
Choi Seong-Min
Kim Byeong-Chae
Kim Joon-Tae
Kim Myeong-Kyu
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Abstract
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Background and Purpose: We investigated the relationship between the β-fibrinogen gene (FGB) -455 G/A
polymorphism and plasma fibrinogen levels in Korean ischemic stroke patients. We also determined whether the
frequency of the -455 G/A polymorphism differed between two subtypes of noncardioembolic stroke: large-artery
atherosclerosis (LAA) and small-vessel occlusion (SVO).
Methods: A total of 267 patients with noncardioembolic stroke were enrolled. Plasma fibrinogen and other risk
factors for stroke were evaluated. FGB -455 G/A genotypes were determined by polymerase chain reaction with
restrictive enzyme Hae III and automatic DNA sequencing.
Results: The FGB -455 G/A polymorphism was significantly associated with an elevated plasma fibrinogen level
(p<0.001). The frequency of the A allele in Korean stroke patients was 16.7%. However, the frequency of the -455
G/A polymorphism did not differ between LAA and SVO.
Conclusions: The plasma fibrinogen level might be affected by the -455 G/A polymorphism in noncardioembolic
stroke patients. However, the LAA and SVO subtypes of ischemic stroke were not affected by the -455 G/A
polymorphism.
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KEYWORD
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Fibrinogen, Polymorphism, Stroke
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